Description
Product Characteristics:
Aliases: apoptosis-related protein PNAS-2 antibody, C9orf83 antibody, CGI 34 antibody, Charged multivesicular body protein 5 antibody, CHMP 5 antibody, CHMP family, member 5 antibody, chmp5 antibody, CHMP5_HUMAN antibody, Chromatin modifying protein 5 antibody, Chromatin-modifying protein 5 antibody, Chromosome 9 open reading frame 83 antibody, HGNC:26942 antibody, HSPC177 antibody, hVps60 antibody, PNAS 2 antibody, SNF7 domain containing protein 2 antibody, SNF7 domain-containing protein 2 antibody, SNF7DC2 antibody, Vacuolar protein sorting 60 antibody, Vacuolar protein sorting-associated protein 60 antibody, Vps60 antibody
Target Information: CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]